Type:10 Capsules
Generic Name:Tamsulosin + Dutasteride
Manufacturer:Popular Pharmaceuticals Ltd.
Price:৳200.00
Benign prostatic hyperplasia
Oral Benign prostatic hyperplasia Adult: 1 cap once daily.
Hypersensitivity, severe liver impairment. Pregnancy, lactation, child, adolescent.
Tamsulosin is a selective alpha-1 adrenoceptor blocker. It blocks alpha-1 adrenoceptors, which are abundant in the prostate, prostatic capsule, prostatic urethra, and bladder neck, resulting relaxation of these adrenoceptors in the bladder neck and prostate. Thus, there is an improvement in urine flow rate and reduction in symptoms of benign prostatic hypertrophy (BPH). Dutasteride inhibits 5 alpha-reductase, the enzyme responsible for conversion of testosterone to 5 alpha-dihydrotestosterone (DHT). DHT appears to be the principal androgen responsible for stimulation of prostatic growth.
Excreted in semen therefore use of condom is recommended. Women of childbearing potential should avoid handling leaking capsules of dutasteride. Prostate carcinoma should be ruled out before starting the therapy. Blood donation to be avoided during and at least 6 mths after discontinuance of drug.
>10% Orthostasis (16%) 1-10% Ejaculation disorders (10%),Dizziness (2%),Breast enlargement/tenderness (3%),Impotence (8%),Decreased libido (4.5%),Breast disorders (1%) <1% Prostate cancer (high grade)
Concomitant admin with moderate or strong inhibitors of CYP2D6 (eg. fluoxetine) or CYP34A (eg. ketoconazole, cimetidine) increases tamsulosin serum concentration; increase in blood concentrations of dutasteride in the presence of inhibitors of CYP3A4/5 such as ritonavir, ketoconazole, verapamil, diltiazem, cimetidine, troleandomycin, and ciprofloxacin.
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