Hydrocort

Hydrocort1%

Type:10gm tube

Generic Name:Hydrocortisone 1% Topical

Manufacturer:Alco Pharma Limited

Price:28.08

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Indication

Corticosteroid-responsive dermatoses, Contact allergic dermatitis, Eczema - atopic; infantile; discoid; stasis, Seborrheic dermatitis, Skin irritations, itching and rashes, for example those caused by insect bites, minor thermal burns, sunburn, etc.

Adult Dose

Corticosteroid-responsive Dermatoses Adult: Apply a thin film onto affected area 2-3 times daily.

Child Dose

Atopic Dermatitis <3 months: Safety and efficacy not established >3 months: Apply film to affected area q12hr Corticosteroid-responsive Dermatoses Apply q6-12hr Dosing considerations Limit to the minimum amount necessary for therapeutic efficacy

Contraindication

Viral/fungal infections, tubercular or syphilitic lesions, bacterial infections unless used in conjunction with appropriate chemotherapy.

Mode of Action

Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency.

Precaution

DM, elderly, patients on prolonged therapy. Pregnancy and lactation. Lactation: Excretion in milk unknown; use with caution

Side Effect

Skin atrophy,Striae,Acneform lesions,Perioral dermatitis,Folliculitis,Itching,Pigmentation changes,HPA suppression (with higher potency used >2 wk)

Interaction

Thiazides may enhance hyperglycaemia and hypokalaemia caused by corticosteroids. Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs admin. Response to anticoagulants altered. Dose of antidiabetics and antihypertensives needs to be increased. Decreases serum conc of salicylates and antimuscarinic agents. Ethanol may enhance gastric mucosal irritation. Reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone, barbiturates and rifampicin. Mutual inhibition of metabolism between ciclosporin and corticosteroids increase plasma conc of both drugs. Enhanced effect in women taking oestrogens or oral contraceptives.

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