Virex

Virex3%

Type:5gm tube

Generic Name:Acyclovir 3% Eye prep

Manufacturer:Nipa Pharmaceuticals Ltd.

Price:100.00

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Indication

As 3% Eye oint: Apply 5 times/day until 3rd day of complete healing.

Administration

Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).

Adult Dose

Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration.

Renal Dose

Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.

Precaution

Herpes simplex keratitis

Pregnancy Category Note

Eye application may produce stinging, superficial punctate keratopathy, blepharitis or conjunctivitis.

Interaction

Hypersensitivity.

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