Alervil

Alervil15mg/5ml

Type:75ml bot

Generic Name:Pheniramine Maleate

Manufacturer:Incepta Pharmaceuticals Ltd.

Price:25.00

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Indication

Allergic conditions, Motion sickness, Allergic conjunctivitis, Allergic rhinitis

Administration

Should be taken with food. Take after meals.

Adult Dose

Oral Allergic conditions Adult: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Elderly: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Prophylaxis of motion sickness Adult: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Take 1st dose at least 30 min before travelling.

Child Dose

Oral Allergic conditions Child: Tablet 5-10 yr: Half a 45-mg tablet up to tid; Tablet: Up to 45 mg tid. >10 yr: Syrup: 15-30 mg bid or tid. Max: 3 mg/kg/day. Prophylaxis of motion sickness Child: As maleate: 5-10 yr: Half a 45-mg tablet up to tid; >10 yr: Syrup: 15-30 mg bid or tid. Tablet: Up to 45 mg tid. Max: 3 mg/kg/day. Take 1st dose at least 30 min before travelling.

Contraindication

Symptomatic prostatic hypertrophy; neonates and premature infants.

Mode of Action

Pheniramine is an alkylamine derivative with histamine H1-receptor antagonist effects. It also has anticholinergic and moderate sedative effects.

Precaution

May impair ability to drive or operate machinery. Has potential for abuse. Narrow angle glaucoma, asthma or severe CV disease. Antiemetic effect may mask signs of other conditions. Pregnancy and lactation. Elderly.

Side Effect

Sedation. Hypersensitivity reactions. Lassitude, dizziness, tinnitus, inability to concentrate, incoordination, irritability, insomnia and tremors. Nausea, vomiting, diarrhoea, colic, epigastric pain, anorexia, dryness of mouth and constipation. Urinary retention. Palpitations, headache. Blurred vision, increased intraocular pressure. Muscular weakness. Rarely, blood dyscrasias e.g. agranulocytosis, haemolytic anaemia.

Interaction

May mask ototoxicity produced by aminoglycoside antibiotics. Potentially Fatal: Potentiation of CNS depression by alcohol, sedatives, opioids, barbiturates, hypnotics, narcoleptics. May increase antimuscarinic effect of MAOIs, atropine and TCAs.

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