Leucofil

Leucofil15mg/5ml

Type:100ml bot

Generic Name:Ambroxol

Manufacturer:Leon Pharmaceuticals Ltd.

Price:40.12

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Indication

Syrup: Adults -10 ml (2 teaspoonful), 3 times a day. SR Capsule : Adults - 1 capsule, once daily

Administration

No clinically relevant unfavourable interaction with other medications has been reported.

Adult Dose

Ambroxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.

Renal Dose

Ambroxol is a metabolite of Bromhexine. It possesses mucokinetic (improvement in mucus transport) and secretolytic (liquefies secretions) properties. Ambroxol stimulates the serous cells of the glands of the mucous membrane of bronchi, increasing the content of mucus secretion. The mucolytic effect is associated with depolymerization and splitting of mucoproteins and mucopolysaccharide fibres, which leads to reduction in the viscosity of mucus. Expectoration of mucus is facilitated and breathing is eased considerably. Ambroxol stimulates production of phospholipids of surfactant by alveolar cells. Ambroxol has anti-inflammatory properties. In patients with COPD, it improves airway patency.

Contraindication

Paediatric Drops : 0 - 6 months old - 0.5 ml, 2 times a day, 6 - 12 months old - 1 ml, 2 times a day, 1 - 2 years old -1.25 ml, 2 times a day. Syrup : 2 -5 years old - 2.5 ml (1/2 teaspoonful), 2-3 times a day, 5 - 10 years old - 5 ml (1 teaspoonful), 2-3 times a day, 10 years old - 10 ml (2 teaspoonful), 3 times a day. SR Capsule : Children over 12 years old - 1 capsule, once daily

Mode of Action

Can be taken with or without food.

Precaution

Mucolytic, Productive cough, Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis, laryngitis, Pharyngitis, sinusitis and rhinitis associated with viscid mucus, Asthmatic bronchitis, bronchial asthma with thick expectoration, Bronchiectasis, Chronic pneumonia.

Pregnancy Category Note

Tablet: Gastrointestinal Disorders: Dyspepsia, nausea, vomiting, diarrhoea and abdominal pain. Immune System, Skin and Subcutaneous Tissue Disorders: Anaphylactic reactions including anaphylactic shock, angioedema, rash, urticaria, pruritus and other hypersensitivity. Syrup: Gastrointestinal, Respiratory, Mediastinal and Thoracic Disorders: Dyspepsia, nausea, vomiting, diarrhoea and abdominal pain; oral and pharyngeal hypoaesthesia; dry mouth and throat. Nervous System Disorders: Dysgeusia (eg, changed taste). Immune System, Skin and Subcutaneous Tissue Disorders: Anaphylactic reactions including anaphylactic shock, angioedema, rash, urticaria, pruritus and other hypersensitivity.

Interaction

Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.

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