Dieta Plus 4

Dieta Plus 430mg+4mg

Type:Tablet

Generic Name:Glimepiride + Pioglitazone

Manufacturer:Pacific Pharmaceuticals Ltd.

Price:15.00

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Indication

Type 2 DM

Adult Dose

Oral Type 2 diabetes mellitus Adult: 30 mg/2 mg, OR 30 mg/4 mg: Initially, 1 tab once daily then titrate gradually as needed. Elderly: Should start w/ glimepiride 1 mg/day prior to initiating pioglitazone + glimepiride combination. Hepatic Impairment 1 mg/day glimpiride PO prior to initiating glimepiride/pioglitazone; titrate conservatively to avoid hypoglycemia Baseline ALT <2.5 xULN: Use caution Baseline ALT >2.5 xULN: Do not initiate ALT >3 xULN or jaundice after initiating therapy: Discontinue

Renal Dose

Renal Impairment CrCl <22 mL/min: 1 mg/day glimepiride PO prior to initiating glimepiride/pioglitazone; titrate conservatively to avoid hypoglycemia Base dose titration on fasting glucose levels CrCl >22 mL/min: 30 mg/2 mg or 30 mg/4 mg PO qDay initially

Contraindication

History of allergic reaction to sulfonamide derivative. Patient w/ established CHF (NYHA class III or IV). Not intended for treatment of type 1 DM or diabetic ketoacidosis.

Mode of Action

Pioglitazone, a thiazolidinedione, reduces blood glucose by improving target cell response to insulin w/o increasing pancreatic insulin secretion and is dependent on the presence of insulin for activity. Glimepiride, a sulfonylurea, stimulates insulin release from the pancreatic beta-cells. It also reduces glucose output from the liver and increases insulin sensitivity at peripheral target sites.

Precaution

Pioglitazone, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when is used in combination with insulin. Fluid retention may lead to or exacerbate congestive heart failure. Patients should be observed for signs and symptoms of congestive heart failure. If congestive heart failure develops, it should be managed according to current standards of care and discontinuation or dose reduction of must be considered. Lactation: Not known if crosses into breast milk, discontinue drug or breastfeeding

Side Effect

>10% Peripheral edema (6-12%),Upper respiratory tract infection (12-15%),Weight gain (9-13%),Hypoglycemia (13-16%) 1-10% Anemia (<2%),Limb pain (4-5%),Urinary tract infection (6-7%),Headache (4-7%),Diarrhea (4-6%),Nausea (4-5%)

Interaction

Increased plasma levels w/ CYP2C8 inhibitors (e.g. gemfibrozil) and CYP2C9 inhibitors (e.g. fluconazole). Decreased plasma levels w/ CYP2C8 inducers (e.g. rifampicin). Colesevelam may reduce the max plasma concentration and total exposure of glimepiride. Concominant use w/ oral miconazole may lead to severe hypoglycaemia.

Alternative brand of Dieta Plus 4

Dieta Plus 2Dieta Plus 2

  • 30mg+2mg
  • Tablet
  • Glimepiride + Pioglitazone

Price: ৳12.50

Pacific Pharmaceuticals Ltd.