Assisted reproductive technologies, In-vitro fertilization
Subcutaneous Assisted reproductive technologies Adult: As acetate: equiv to 0.25 mg cetrorelix either in the morning beginning on the day 5 or 6 of ovarian stimulation or in the evening beginning on day 5, and continued until ovulation induction.
Severe renal impairment: Contraindicated
Hypersensitivity. Moderate to severe renal or hepatic impairment. Women with severe allergic conditions. Pregnancy and lactation;
Cetrorelix, a synthetic decapeptide analog of naturally occurring gonadorelin, is a gonadorelin antagonist. It competitively blocks gonadorelin receptors on the anterior piyuitary gonadotroph and the subsequent transduction pathway, inducing a rapid, reversible suppression of gonadotrophin secretion.
Women with active allergic conditions or a history of allergies; childn; elderly >65 yrs Lactation: Excretion in milk unknown/contraindicated
1-10% Ovarian hyperstimulation syndrome (4%),Nausea (1%),Hepatic enzyme elevation (1-2%),Headache (1%) <1% Erythema at injection site,Itching,Pruritus,Swelling,Redness,Hypotension,Rash,Cough
Pregnancy Category: X Lactation: Excretion in milk unknown/contraindicated
In vitro investigations have shown that interactions are unlikely with medications that are metabolised by cytochrome P-450 or glucuronised or conjugated in some other way. However, the possibility of interactions with commonly used medicinal products can not entirely be excluded.