Osmotic IV Infusion

Osmotic IV Infusion20%

Type:500ml bot

Generic Name:Mannitol 20%

Manufacturer:Popular Pharmaceuticals Ltd.

Price:155.00

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Indication

Chronic bronchitis, Cerebral oedema, Oliguric phase of renal failure, Raised intracranial pressure, Renal function testing, Transurethral prostatic resection

Adult Dose

Intravenous Oliguric phase of renal failure Adult: 50-100 g in a 24-hr period by IV infusion. Adjust rate of administration to maintain a urine flow of at least 30-50 mL/hr. Cerebral oedema, Reduction of raised intraocular pressure Adult: 0.25-2 g/kg by IV infusion given over 30-60 minutes. Renal function testing Adult: 0.2 g/kg infused over 3-5 min.

Child Dose

Intravenous Edema 0.25-1 g/kg IV initially; maintenance dose of 0.25-0.5 g/kg IV q4-6hr Anuria/Oliguria Test dose: 0.2 g/kg IV over 3-5 minutes; not to exceed 12.5 g Discontinue if no diuresis within 2 hr

Contraindication

Pulmonary congestion or oedema; intracranial bleeding; CHF; metabolic oedema with abnormal capillary fragility; anuria due to severe renal disease; severe dehydration.

Mode of Action

Mannitol increases urinary output by inhibiting tubular reabsorption of water and electrolytes. It raises the osmotic pressure of the plasma allowing water to be drawn out of body tissues.

Precaution

Hypervolaemia; urinary tract obstruction; check for signs of fluid and electrolyte imbalance. Should not be administered with whole blood. Pregnancy, lactation.

Side Effect

Fluid and electrolyte imbalance; acidosis (with high doses). Nausea, vomiting, thirst; headache, dizziness, convulsions, chills, fever; tachycardia, chest pain; blurred vision; urticaria and hypotension or hypertension; acute renal failure; skin necrosis; thrombophloebitis.

Interaction

Increased nephrotoxicity with ciclosporin.

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