Type:Tablet
Generic Name:Valdecoxib
Manufacturer:Novartis (Bangladesh) Ltd.
Price:৳10.00
Osteoarthritis, Rheumatoid arthritis, Dysmenorrhoea
May be taken with or without food.
Oral Osteoarthritis, Rheumatoid arthritis Adult: 10 mg once daily. Dysmenorrhoea Adult: 20 mg bid. Hepatic Impairment Child-Pugh scale 7-9: Initiate with caution. Child-Pugh scale >10: Avoid.
Renal Impairment CrCl Dosage <30 Initiate with caution.
Hypersensitivity to sulfonamides, NSAIDs and other COX 2 inhibitors; asthma, urticaria; severe hepatic impairment; pregnancy (third trimester); lactation. Active GI bleed or ulceration, severe CHF, inflammatory bowel disease.
Valdecoxib acts by selectively inhibiting prostaglandin synthesis primarily by blocking cyclooxygenase (COX-2) enzyme. It was withdrawn worldwide, following risk of serious skin reactions and cardiovascular side effects.
Mild to moderate hepatic impairment; history of ulcer disease or GI bleeding; dehydration, hypertension, history of heart failure, left ventricular dysfunction, pre-existing oedema. Monitor Hb or haematocrit values for signs and symptoms of anaemia.
Hypertension, back pain, myalgia, peripheral oedema, influenza-like symptoms, dizziness, headache, abdominal fullness, abdominal pain, diarrhoea, dyspepsia, flatulence, nausea, myalgia, sinusitis. Potentially Fatal: Toxic epidermal necrolysis, exfoliative dermatitis.
Concomitant admin of aspirin may result in an increased risk of GI ulceration and complications. It decreases the antihypertensive effect of antihypertensives e.g. ACE inhibitors. It increases plasma conc of dextromethorphan. It significantly decreases lithium serum clearance and renal clearance.