Type:Tablet
Generic Name:Tinidazole
Manufacturer:Beacon Pharmaceuticals Ltd.
Price:৳5.70
Giardiasis, H. pylori infection, Surgical Prophylaxis, Bacterial vaginosis, Intestinal amoebiasis, Trichomoniasis, Acute necrotising ulcerative gingivitis, Hepatic amoebiasis
Should be taken with food. Take during or immediately after meals.
Oral Bacterial vaginosis Adult: 2 g as single dose. May also be given as 2 g for 2 consecutive days or 1 g daily for 5 days. Anaerobic bacterial infections Adult: 2 g on the 1st day, followed by 1 g daily or 500 mg bid for 5-6 days. Prophylaxis of postoperative anaerobic bacterial infections Adult: 2 g as single dose 12 hr before surgery. Eradication of H. pylori associated with peptic ulcer disease Adult: 500 mg bid, given w/ clarithromycin and omeprazole for 7 days. Intestinal amoebiasis Adult: 2 g daily for 2 or 3 days. Hepatic amoebiasis Adult: 1.5-2 g daily for 3-6 days. Giardiasis Adult: 2 g as single dose. Trichomoniasis; Acute necrotising ulcerative gingivitis Adult: 2 g as single dose. In trichomoniasis, sexual partners should be treated at the same time. Intravenous IV Susceptible infections Initial: Infuse 800 mg, followed by 800 mg/day or 400 mg twice daily till PO can be given. Surgical prophylaxis 1.6 g as single infusion pre-op.
Oral Intestinal amoebiasis Child: >3 yr 50-60 mg/kg daily for 3 consecutive days. Max: 2 g/day. Hepatic amoebiasis Child: >3 yr 50-60 mg/kg daily for 5 days. Max: 2 g/day. Giardiasis Child: >3 yr 50-75 mg/kg as single dose, repeat if necessary. Max: 2 g/day.
Renal impairment: Haemodialysis: Additional dose equal to half the usual dose at the end of haemodialysis.
Blood dyscrasias, organic neurologic disorders, hypersensitivity to 5-nitroimidazole derivatives, porphyria. Lactation, pregnancy (1st trimester).
Tinidazole, a 5-nitroimidazole derivative w/ antimicrobial actions similar to metronidazole, is active against both protozoa (e.g. Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia) and obligate anaerobic bacteria. It damages DNA strands or inhibits DNA synthesis in microorganism.
Patient w/ current or a history of blood dyscrasias. Pregnancy (2nd and 3rd trimester). Hepatic and renal impairment. Monitoring Parameters Monitor total and differential leukocyte counts. Closely monitor childn when treatment duration exceeds 3 days. Lactation: discontinue nursing while taking drug & for 3 d after last dose
1-10% Anorexia (2-3%),Constipation (<1%),Dizziness (<1%),Dysgeusia (4-6%),Dyspepsia (1-2%),Headache (<1%),Nausea (3-5%),Vomiting (1-2%),Weakness/fatigue/malaise (1-2%) Frequency Not Defined Ataxia,Candida overgrowth,Convulsions & transient peripheral neuropathy,Numbness & paresthesia,Diarrhea,Darkened urine,Tongue discoloration,Transient leukopenia/neutropenia Potentially Fatal: Hypersensitivity.
May potentiate the effects of oral anticoagulants resulting to prolonged prothrombin time.