Type 2 DM
Take immediately before or up to ½ hr before meals.
Oral Type 2 diabetes mellitus Adult: 60 or 120 mg tid.
Diabetic ketoacidosis; IDDM. Lactation.
Nateglinide, a nonsulfonylurea hypoglycaemic agent, acts by stimulating insulin release from pancreatic ?-cells to reduce postprandial hyperglycaemia. This action depends on the amount of existing glucose levels.
Geriatric patients, debilitated and malnourished patients; adrenal or pituitary insufficiency, moderate to severe hepatic impairment; severe renal impairment. Monitor glycaemic levels during periods of stress. Pregnancy. Lactation: unsafe
1-10% Increased uric acid (10%),Dizziness (4%),Arthropathy (3%),Flu-like syndrome,Weight gain,Hypoglycemia (2%) Frequency Not Defined Diarrhea,Nausea
Increased levels/effects with enzyme inhibitors (e.g. fluconazole). Increased hypoglycaemic effects with salicylates, MAOIs, nonselective beta-blockers, alcohol, NSAIDs. Decreased levels/effects with enzyme inducers (e.g. rifampicin). Decreased hypoglycaemic effects with thiazide diuretics, corticosteroids, thyroid products and sympathomimetic agents.