Secnid DS

Secnid DS1gm

Type:2 Tablets

Generic Name:Secnidazole

Manufacturer:Square Pharmaceuticals PLC.

Price:40.00

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Indication

Giardiasis, Amoebiasis, Trichomoniasis

Adult Dose

Oral Trichomoniasis; Amoebiasis; Giardiasis Adult: 2 g as a single dose. Severe invasive amoebiasis Adult: 1.5 g daily as single or in divided doses for 5 days.

Child Dose

Oral Trichomoniasis; Amoebiasis; Giardiasis Child: 30 mg/kg as a single dose. Severe invasive amoebiasis Child: 30 mg/kg daily for 5 days.

Contraindication

Hypersensitivity; pregnancy (1st trimester) and lactation.

Mode of Action

Secnidazole is active against E histolytica, G lamblia, T vaginalis, Clostridium spp, B fragilis, Gardnerella spp. The drug enters the microorganisms by diffusion and is reduced intracellularly by low oxidation-reduction potential ferredoxin which then result in DNA damage.

Precaution

Avoid alcohol and disulfiram. Avoid in patients with history of blood disorders.

Side Effect

Nausea, gastralgia, change of taste, metallic taste, stomatitis, urticaria, rashes, leucopenia. Rarely vertigo, moderate neurological, digestive disturbances.

Interaction

Concurrent disulfiram admin may cause psychotic reactions. Disulfiram-like reactions with alcohol. Cimetidine may prolong half-life. Potentially Fatal: May potentiate anticoagulant effect of warfarin and increase risk of haemorrhage.

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