Type:6 Tablets
Generic Name:Pyridostigmine
Manufacturer:Popular Pharmaceuticals Ltd.
Price:৳150.54
Reversal of neuromuscular blockade, Myasthenia gravis, Paralytic ileus, post-operative urinary retention
Should be taken with food.
Oral Myasthenia gravis Adult: 30-120 mg in divided doses, up to a total daily dose of 0.3-1.2 g. Paralytic ileus and postoperative urinary retention Adult: 60-240 mg daily.
Oral Myasthenia gravis Child: <6 yr Initially, 30 mg; 6-12 yr Initially, 60 mg. Doses are repeated throughout the day up to a usual total daily dose of 30-360 mg, w/ increments of 15-30 mg daily until a satisfactory response is obtained. Paralytic ileus and postoperative urinary retention Child: 15-60 mg daily.
Renal impairment: Lower initial dose may be needed, titrate to desired effect.
Mechanical GI or urinary obstruction.
Pyridostigmine bromide facilitates impulse transmission across the myoneural junction by inhibiting the destruction of acetylcholine by acetylcholinesterase. It also has direct cholinomimetic effect on skeletal muscles.
Patient w/ bronchial asthma, COPD, bradycardia, cardiac arrhythmias, vagotonia, peptic ulcer, epilepsy or parkinsonism, hyperthyroidism. Renal impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor cholinergic reaction particularly in IV admin.
Nausea, vomiting, diarrhoea, increased peristalsis and bronchial secretions, miosis, excessive salivation and sweating, abdominal cramps, bradycardia, bronchospasm, skin rash, muscle spasm, fasciculation, muscle weakness. Potentially Fatal: Resp paralysis, cardiac arrest, pulmonary oedema.
May exacerbate night vision problems w/ anti-glaucoma drugs. Antagonises the effect of non-depolarising muscle relaxants (e.g. pancuronium, vecuronium). Prolongs the effect of depolarising muscle relaxants (e.g. suxamethonium).
