Type:Tablet
Generic Name:Estrogens
Manufacturer:
Price:৳2.02
Breast cancer, Prostate cancer, Hormone replacement therapy, Oral contraceptives
Menopausal Vasomotor Symptoms, Atrophic Vaginitis/Kraurosis Vulvae 0.3 mg PO once daily in either continuous daily regimen or cyclic regimen (25 days on, 5 days off); adjusted PRN; use lowest dose that control symptoms; may be given daily if medical assessment warrants it Female Hypogonadism 0.3-0.625 mg PO once daily in cyclic regimen (3 weeks on, 1 week off); may be titrated every 6-12 months; adjusted PRN; add progestin treatment should be added to maintain bone mineral density once skeletal maturity achieved Osteoporosis Prophylaxis 0.3 mg PO once daily in cyclic regimen (25 days on, 5 days off); adjusted PRN based on clinical response; may be given daily if medical assessment warrants it; administer lowest effective dose May also be used in combination with medroxyprogesterone acetate Prostate Cancer Palliation only 1.25-2.5 mg PO q8hr Abnormal Uterine Bleeding 10-20 mg/day PO divided q4hr May administer low dose medroxyprogesterone acetate with therapy or following therapy Cyclic therapy: 25 days on, 5 days off; either 3 weeks on, 1 week off Female Castration/Primary Ovarian Failure 1.25 mg PO once daily in cyclic regimen (25 days on, 5 days off); adjusted PRN; administer lowest effective dose Breast Cancer Palliation Metastatic disease in selected patients (males and females):10 mg PO q8hr for ?3 months
Severe liver impairment; breast carcinoma; thromboembolic disorders; CV disease; undiagnosed vag bleeding; estrogen-dependent neoplasms; hypersensitivity; pregnancy.
Estrogens modulate pituitary secretion of gonadotropins, leutinising hormones and follicle-stimulating hormones through -ve feedback mechanism, thus reducing elevated levels of hormones in postmenopausal women during oestrogen replacement therapy.
Asthma, epilepsy, migraine; heart or kidney dysfunction; CV disease; cerebrovascular disorders; diabetes, hypercalcaemia; gall bladder disease; porphyria. Childn. Lactation. Lactation: Use controversial; estrogens are excreted into breast milk in small quantities; use with caution
>10% Abdominal pain (15-17%),Back pain (13-14%),Breast enlargement,Breast tenderness (7-12%),Headache (26-32%),Arthralgia (7-14%),Pharyngitis (10-12%),Sinusitis (6-11%),Diarrhea (6-7%) 1-10% Depression (5-8%),Dizziness (4-6%),Nervousness (2-5%),Flatulence (6-7%),Vaginitis (5-7%),Leukorrhea (4-7%),Leg cramps (3-7%),Increased cough (4-7%),Pruritus (4-5%) Frequency Not Defined Amenorrhea,Breakthrough bleeding,Corneal curvation change,Melasma,Spotting,Vaginal moniliasis,Weight changes Potentially Fatal: Unopposed replacement therapy in postmenopausal women associated with increased risk of endometrial and breast cancer.
Pregnancy Category: X Lactation: Controversial; estrogens are excreted into breast milk in small quantities, use caution
Rifampicin, barbiturates increase rate of metabolism. Potentially Fatal: May reduce the efficacy of anticoagulants.