Contraception, Menstrual disorders
May be taken with or without food.
Oral Menstrual disorders Adult: 5-10 mg daily as cyclic regimen.
Undiagnosed vaginal bleeding, active venous thromboembolic disorders or severe arterial disease, hepatic impairment, progestogen-dependent tumours, porphyria. Pregnancy.
Lynestrenol is a progestogen structurally related to norethisterone. It may be used alone or as the progestogenic component of some oral contraceptives.
CV or renal dysfunction, hypertension, epilepsy, migraine, asthma, DM, conditions which may be exacerbated by fluid retention, malabsorption syndrome, post ectopic pregnancy, functional ovarian cysts, thromboembolism. Lactation.
GI disturbances, changes in appetite or weight, fluid retention, oedema, rashes, urticaria, mental depression, breast tenderness and pain, gynaecomastia, changes in libido, headache, migraine, altered menstrual cycle, irregular menstrual bleeding, changes in LFTs and serum lipid profile. Potentially Fatal: Anaphylaxis or anaphylactoid reactions.
Increased metabolism and subsequent reduction in efficacy with enzyme-inducing agents e.g. carbamazepine, griseofulvin, phenobarbital, phenytoin and rifampicin. Adjustment in antidiabetic dose may be required. Potentially Fatal: May increase plasma levels and toxicity of ciclosporin.