Type:Tablet
Generic Name:Nelfinavir
Manufacturer:Square Pharmaceuticals PLC.
Price:৳45.30
HIV infection
Should be taken with food.
Oral HIV infection Adult: Combined with other antiretrovirals: 1.25 g bid or 0.75 g tid. Hepatic Impairment Mild impairment (Child-Pugh class A): Dose adjustment not necessary Severe impairment (Child-Pugh Class B or C): Not recommended
Oral HIV infection Child: Combined with other antiretrovirals: 2-13 yr: 45-55 mg/kg bid or 25-35 mg/kg tid. Max: 0.75 g tid. Max Dosage: Child: 0.75 g tid.
Renal Impairment Dose adjustment not necessary
Hypersensitivity; lactation.
Nelfinavir is a selective, competitive, reversible HIV protease inhibitor. It inhibits HIV-1 protease preventing the cleavage of the gag-pol polyprotein resulting in the production of noninfectious virus.
Pregnancy. Hepatic and renal impairment; haemophilia A or B; diabetes. Monitor for signs of lipodystrophy. Lactation: HIV+ women are advised not to breastfeed
>10% Diarrhea (14-20%) 1-10% Nausea (3-7%),Flatulence (1-5%),Abdominal pain (1%),Anemia (1%),Allergic reaction (1%),Impaired concentration (1%),Lipodystrophy (1%),Metabolic acidosis (1%),Rash (1-3%),Leukopenia (1%),Thrombocytopenia (1%),Weakness (1%) <1% QTc prolongation,Torsades de pointes,Diabetes mellitus, new onset and exacerbation,Hyperglycemia
Reduced levels/effects with antacids, phenobarbital, carbamazepine, aminoglutethimide, phenytoin, rifampicin, nafcillin, nevirapine, omeprazole, nevirapine. Increased serum levels/effects with azole antifungal agents, cimetidine, efavirenz. Increased serum levels/effects of azithromycin, calcium channel blockers, clarithromycin, corticosteroids (e.g. fluticasone), mirtazapine, nateglinide, nefazodone, ciclosporin, sirolimus, tacrolimus, venlafaxine, eplerinone, fentanyl, atorvastatin, phosphodiesterase-5 (PDE-5) inhibitors, rifabutin, trazodone, TCAs. Reduced serum levels/effects of hormonal contraceptives, methadone, theophylline derivatives. Potentially Fatal: Increased serum levels/toxicity of amiodarone, cisapride, pimozide, midazolam, triazolam, ergot alkaloids, lovastatin, simvastatin, quinidine.