Loracef

Loracef500mg

Type:6 Capsules

Generic Name:Cefaclor

Manufacturer:Square Pharmaceuticals PLC.

Price:229.56

Ad

Indication

Pneumonia, Meningitis, Peritonitis, Otitis media, Septicaemia, Biliary-tract infections, Urinary-tract infections, Skin and skin structure infections, Upper and lower respiratory tract infections, Pharyngitis, Tonsillitis

Administration

May be taken with or without food.

Adult Dose

Oral Urinary tract infections, Upper and lower respiratory tract infections, Skin infections, Otitis media Adult: As monohydrate: 250-500 mg every 8 hr. Max: 4 g daily.

Child Dose

Oral Urinary tract infections, Upper and lower respiratory tract infections, Skin infections, Otitis media Child: PO 20–40 mg/kg/day, max 1 g/day q12h 1-5 yr: 125 mg tid, >5 yr: 250 mg tid. Suspension & Paediatric Drops: 1 month - 1 year 2.5 ml t.i.d. 0.625 ml t.i.d 1 year - 5 year 5 ml t.i.d. 1.25 ml t.i.d over 5 years 10 ml t.i.d 2.5 ml t.i.d

Renal Dose

Renal Impairment CrCl: 10-50 mL/min: Half to full dose CrCl: <10 mL/min: Half dose

Contraindication

Known hypersensitivity to cephalosporins.

Mode of Action

Cefaclor binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. It has bactericidal activity against gm-ve bacteria including E. coli, S. pneumoniae, N. gonorrhoea, P. mirabilis and H. influenzae.

Precaution

Severe renal impairment; history of allergy to penicillin; pregnancy, lactation. Lactation: enters breast milk; use with caution

Side Effect

1-10% Diarrhea (3%),Increased transaminases (3%),Eosinophilia (2%),Moniliasis (2%),Vaginitis (2%),Rash (maculopapular, erythematous, or morbiliform) (1-2%) <1% Stevens-Johnson syndrome,Pseudomembranous colitis,Nausea,Vomiting,Anemia,Neutropenia,Jaundice Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.

Pregnancy Category Note

Pregnancy No adequate and well-controlled studies in pregnant women Because animal reproduction studies are not always predictive of human response, cefaclor should be used during pregnancy only if necessary Lactation Effect on nursing infants is unknown; exercise caution when cefaclor is administered to a nursing woman Extended-release tablets No studies in lactating women performed; small amounts of cefaclor (?0.21 mcg/mL) detected in human milk following administration (single 500-mg dose of cefaclor extended-release tablets)

Interaction

May enhance the nephrotoxic effect of aminoglycosides. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. Concomitant use w/ warfarin may increase prothrombin time. Probenecid inhibits renal excretion of cefaclor.

Alternative brand of Loracef

Ceflon 500Ceflon 500

  • 500mg
  • Capsule
  • Cefaclor

Price: ৳30.00

Eskayef Pharmaceuticals Ltd.

CeflonCeflon

  • 250mg
  • Capsule
  • Cefaclor

Price: ৳16.00

Eskayef Pharmaceuticals Ltd.

CeflonCeflon

  • 125mg/5ml
  • Powder for Suspension
  • Cefaclor

Price: ৳200.00

Eskayef Pharmaceuticals Ltd.

CeflonCeflon

  • Paediatric Drops
  • Cefaclor

Price: ৳125.00

Eskayef Pharmaceuticals Ltd.

CefticlorCefticlor

  • Paediatric Drops
  • Cefaclor

Price: ৳125.00

Renata Limited

CeclorCeclor

  • 250mg
  • Capsule
  • Cefaclor

Price: ৳0.00

ClobacClobac

  • Paediatric Drops
  • Cefaclor

Price: ৳125.88

Opsonin Pharma Limited

XclorXclor

  • 125mg/5ml
  • Powder for Suspension
  • Cefaclor

Price: ৳190.57

Orion Pharma Ltd.

ClocefClocef

  • 500mg
  • Capsule
  • Cefaclor

Price: ৳45.00

Amico Laboratories Ltd.

OticlorOticlor

  • Paediatric Drops
  • Cefaclor

Price: ৳125.00

Incepta Pharmaceuticals Ltd.

CefticlorCefticlor

  • 500mg
  • Capsule
  • Cefaclor

Price: ৳38.14

Renata Limited

ClorocefClorocef

  • Paediatric Drops
  • Cefaclor

Price: ৳130.00

The Ibn Sina Pharmaceutical Ind. Ltd.

Clobac 500Clobac 500

  • 500mg
  • Capsule
  • Cefaclor

Price: ৳38.00

Opsonin Pharma Limited

Abaclor 500Abaclor 500

  • 500mg
  • Capsule
  • Cefaclor

Price: ৳40.27

ACI Limited

CefticlorCefticlor

  • 250mg
  • Capsule
  • Cefaclor

Price: ৳21.08

Renata Limited

OticefOticef

  • 250mg
  • Capsule
  • Cefaclor

Price: ৳0.00

Alco Pharma Limited

NavacefNavacef

  • 250mg
  • Capsule
  • Cefaclor

Price: ৳21.04

Navana Pharmaceuticals Ltd.

Ceclor CDCeclor CD

  • 375mg
  • Tablet
  • Cefaclor

Price: ৳43.38

ClobacClobac

  • 125mg/5ml
  • Powder for Suspension
  • Cefaclor

Price: ৳181.00

Opsonin Pharma Limited

CefticlorCefticlor

  • 375mg
  • Tablet Extended Release
  • Cefaclor

Price: ৳30.11

Renata Limited