Corticosteriod-responsive dermatoses w/ secondary infection
Topical/Cutaneous Corticosteriod-responsive dermatoses with secondary infection Adult: Apply to the affected area(s) bid. Max duration: 2 wk.
Skin lesions of viral, fungal or bacterial origin, acne rosacea and perioral dermatitis.
Betamethasone valerate is a topical corticosteroid that is effective in inflammatory dermatoses. Topical fusidic acid is effective against Staphyloccus aureus, Streptococci, Corynebacteria, Neisseria and some Clostridia and bacteroides. Antibacterial activity of fusidic acid is not reduced when used with betamethasone.
Avoid prolonged continuous treatment especially in infants and children. Extended treatment may increase the risk of contact sensitisation and development of antibiotic resistance. Not to be used for >7 days if there is no clinical improvement. Increased risk of glaucoma if preparation enters the eye(s). Pregnancy and lactation.
Prolonged intensive treatment may cause local atrophic changes in the skin e.g. striae, thining and dilatation of superficial blood vessels. Dryness, itching, irritation, hypopigmentation, burning sensation at the site of application or miliaria.
Fucidic Acid: Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin. Betamethasone : Increased hyperglycaemia and hypokalaemia with thiazide diuretics. Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs admin. Response to anticoagulants altered. Dose of antidiabetics and antihypertensives needs to be increased. Decreases serum conc of salicylates and antimuscarinic agents. Potentially Fatal: Reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone, barbiturates and rifampicin. Enhanced effect in women taking oestrogens or oral contraceptives.