Edimox 250

Edimox 250250mg

Type:Tablet

Generic Name:Acetazolamide

Manufacturer:Gaco Pharmaceuticals(G.A Company Ltd)

Price:2.00

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Indication

Adult: PO Diuresis 250-375 mg/day. Glaucoma; Epilepsy 250-1,000 mg/day. Prophylaxis of high altitude sickness 500-1,000 mg/day. Epilepsy >12 years Tablet: 8-30 mg/kg/day PO qDay or divided q6-12 hr; not to exceed 30 mg/kg/day or 1 g/day Acute Altitude Sickness >12 years Immediate release: 500-1000 mg/day PO divided q8-12hr Hepatic impairment: Contraindicated in marked hepatic impairment.

Administration

Concomitant use w/ high-dose aspirin may cause anorexia, tachypnoea, lethargy, metabolic acidosis, coma and death. May increase serum levels of phenytoin, resulting to increased risk of osteomalacia. May decrease serum concentrations of primidone. Additive effects w/ other carbonic anhydrase inhibitors. May increase the effects of folic acid antagonists. May decrease urinary excretion of amphetamine and quinidine. May prevent the urinary antiseptic effect of methenamine. May increase lithium excretion. Increased risk of renal calculus formation w/ Na bicarbonate. May increase ciclosporin levels.

Adult Dose

Potassium supplements may be required. Impaired hepatic or renal function; diabetes. Monitor plasma electrolytes and blood count regularly. IM route is not recommended. Caution when driving or operating machinery. Elderly. Lactation: Enters breast milk; not recommended

Renal Dose

Acetazolamide specifically inhibits the enzyme carbonic anhydrase which catalyses the reversible reaction involving the hydration of CO2 and dehydration of carbonic acid. It increases the excretion of HCO3 ions and as well as Na and K leading to alkaline diuresis. Carbonic anhydrase is also inhibited in the CNS to retard abnormal and excessive discharge from neurons.

Contraindication

<12 years: Safety and efficacy is not established

Mode of Action

Should be taken with food.

Precaution

Glaucoma, Epilepsy, Idiopathic intracranial hypertension, Altitude sickness

Side Effect

Renal impairment: Contraindicated in marked renal impairment.

Pregnancy Category Note

Drowsiness, paraesthesia, ataxia, dizziness, thirst, anorexia, headache; confusion, malaise, depression; GI distress, metabolic acidosis, polyuria, hyperuricaemia, renal calculi, nephrotoxicity, hepatic dysfunction. Potentially Fatal: Rarely, skin reactions or blood dyscrasias.

Interaction

Hypersensitivity to sulphonamides; sodium or potassium depletion, hepatic insufficiency; hepatic cirrhosis; hyperchloraemic acidosis; severe renal impairment; severe pulmonary obstruction; chronic noncongestive angle-closure glaucoma; adrenocortical insufficiency. Pregnancy, lactation.

Alternative brand of Edimox 250

RemoxRemox

  • 250mg
  • Tablet
  • Acetazolamide

Price: ৳2.00

Reman Drug Laboratories Ltd.

AcemoxAcemox

  • 250mg
  • Tablet
  • Acetazolamide

Price: ৳40.00

The ACME Laboratories Ltd.