Dot

Dot40mg/2ml

Type:Injection

Generic Name:Drotaverine Hydrochloride

Manufacturer:The ACME Laboratories Ltd.

Price:7.02

Ad

Indication

Gastrointestinal tract spasm, Irritable bowel syndrome, Dysmenorrhea, Biliary colics, Renal colics

Administration

May be taken with or without food.

Adult Dose

Oral As an antispasmodic Adult: 1 to 2 tablets, 3 times daily. Injection: Adults: 1 to 2 ampoules, intramuscularly or subcutaneously, 1-3 times daily. For the management of acute stone colics: 1 or 2 ampoules by slow intravenous injection.

Child Dose

Oral As an antispasmodic Children (over 6 years): 1/2 to 1 tablet, 1-2 times daily. 40 mg 1-2 times daily Children (1-6 years): 1/4 to 1/2 tablet, 1-2 times daily. 20 mg 1-2 times daily

Contraindication

Severe renal/hepatic/cardiac dysfunction. Porphyria.

Mode of Action

Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.

Precaution

Exercise caution in patients with renal/hepatic/cardiac dysfunction. Pregnacy, lactation.

Side Effect

Vertigo, nausea, vomiting, dry mouth.

Interaction

May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.

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