Bonemas

Bonemas70mg

Type:Tablet

Generic Name:Alendronic Acid (Alendronate)

Manufacturer:Incepta Pharmaceuticals Ltd.

Price:30.00

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Indication

Adult: PO Osteoporosis 10 mg/day or 70 mg once wkly. Prevention of postmenopausal osteoporosis 5 mg/day or 35 mg once wkly. Corticosteroid-induced osteoporosis 5 mg/day; up to 10 mg/day in women not on HRT treatment. Paget's disease of bone 40 mg/day for 6 mth. May repeat after an interval of 6 mth if needed.

Administration

Concomitant iron, calcium supplements and antacids hinder alendronate absorption. Concomitant aspirin or NSAIDs may increase the incidence of adverse GI effects.

Adult Dose

Upper GI disorders (discontinue if symptoms worsen); history of ulcers, active GI bleeding. Correct vitamin D and calcium deficiency before starting therapy. To be taken half an hr before breakfast and remain upright for at least 30 minutes after admin. Not recommended for use in patients with CrCl <35 ml/min. Lactation: Unknown whether drug is excreted in milk; use with caution.

Renal Dose

Alendronic acid reduces bone resorption by inhibiting the action of osteoclasts.

Mode of Action

Administration Take only in morning, not at bedtime or before arising Take tablet with full glass of water (6-8 oz) at least 30 minutes before first food or drink of day, in upright position Administer oral solution with at least 2 ounces of water Swallow with plain water only; mineral water, coffee, juice or other beverages severely reduces bioavailability Swallow tablet whole; do not suck or chew Do not lie down for 30 minutes after taking drug; sit or stand upright

Precaution

Osteopetrosis, postmenopausal osteoporosis, Paget's disease of bone.

Side Effect

Renal impairment: CrCl (ml/min) <35 Not recommended.

Pregnancy Category Note

>10% Hypocalcemia, transient and mild (18%) 1-10% Hypophosphatemia, transient and mild (10%),Abdominal pain (7%),Musculoskeletal pain (4.1%),Dyspepsia (3.6%),Nausea (3.6%),Constipation (3.1%),Diarrhea (3.1%),Flatulence (2.6%),Headache (2.6%),Acid regurgitation (2%),Esophagitis (1.5%),Abdominal distention (1%) <1% Alopecia,Diaphyseal femur fracture,Esophageal cancer,Flu like syndrome,Gastritis,Myalgia,Oropharyngeal ulceration,Pruritus,Rash,Taste perversion,Toxic epidermal necrolysis,Uveitis,Vertigo,Weakness

Interaction

Hypocalcaemia; oesophageal abnormalities and factors which delay oesophageal emptying; severe renal impairment; hypersensitivity; inability to stand or sit upright for ?30 min. Pregnancy, lactation.

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