Medicase - Arbitan Plus 300 - Tablet - 12.5mg+300mg - Hydrochlorothiazide + Irbesartan

Arbitan Plus 30012.5mg+300mg

Type:Tablet

Generic Name:Hydrochlorothiazide + Irbesartan

Manufacturer:Opsonin Pharma Limited

Price:৳24.17

Indication

Diabetic nephropathy, Hypertension

Adult Dose

Hypertension 150 mg/12.5 mg PO qDay intially; if needed, after 1-2 weeks may titrate up to 300 mg/25 mg PO qDay

Contraindication

Hypersensitivity; pregnancy and lactation.

Mode of Action

Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions. Irbesartan is an angiotensin II receptor antagonist. It blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by binding to AT1 receptors.

Precaution

Child <6 yr. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy. Lactation: discontinue drug or do not nurse

Side Effect

>10% Irbesartan Hyperkalemia (19%) 1-10% Chest pain (2%),Tachycardia (1%),Abnormal urination (2%),Musculoskeletal pain (6%),Flu-like syndrome (3%),Edema (3%),Tachycardia (1%),Chest pain (2%),Creatinine increased (1%),Increased BUN (2%) Irbesartan Dizziness (10%),URI (9%),Orthostatic hypotension (5%),Fatigue (4%),Diarrhea (3%),Dyspepsia (2%) Frequency Not Defined Hydrochlorothiazide Anorexia,Epigastric distress,Hypotension,Orthostatic hypotension,Photosensitivity,Anaphylaxis,Anemia,Confusion,Erythema multiforme,Stevens-Johnson syndrome,Exfoliative dermatitis including toxic epidermal necrolysis,Dizziness,Hypokalemia and/or hypomagnesemia,Hyperuricemia,Headache

Pregnancy Category Note

Pregnancy Category: C (1st trimester); D (2nd & 3rd trimesters)

Interaction

Other antihypertensives, lithium, K-sparing diuretics, K supplements, salt substitutes containing K. CNS depressants, antidiabetics, cholestyramine & colestipol resins, corticosteroids, ACTH, digitalis glycosides, antiarrhythmics, NSAIDs, tubocurarine, antigout medications, Ca salts. Alcohol; ?-blockers, diazoxide, atropine, beperiden, amantadine, cyclophosphamide, methotrexate.