Acflam

Acflam100mg

Type:Tablet

Generic Name:Aceclofenac

Manufacturer:Apollo Pharmaceutical Laboratories Ltd.

Price:4.00

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Indication

Adult: PO Ankylosing spondylitis; Osteoarthritis; Rheumatoid arthritis 100 mg twice daily. SR Tablet : The recommended dose is 200 mg, once daily. Elderly: The pharmacokinetics of aceclofenac are not altered in elderly patients, therefore it is not considered necessary to modify the dose and dose frequency. Hepatic Impairment Reduce initial dose to 100 mg daily .

Administration

May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones.

Adult Dose

Cautiously administer to patients with GI disease, ulcerative colitis, Crohn's disease, haematological abnormalities, hepatic porphyria; history of bronchial asthma; history of heart failure or hypertension; mild renal, hepatic or cardiac impairment. May impair ability to drive or operate machinery. Elderly. Patients suffering from severe hepatic impairment must be monitored.

Renal Dose

Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.

Contraindication

Safety & Efficacy not established.

Mode of Action

Should be taken with food. Take w/ or immediately after meals.

Precaution

Indicated for the relief of pain and inflammation in both acute and chronic pain like, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, dental pain, post-traumatic pain, low back pain, gynaecological pain.

Side Effect

No dose adjustment needed.

Pregnancy Category Note

Gastrointestinal disorders (dyspepsia, abdominal pain, nausea and diarrhoea) and occasional occurance of dizziness. Dermatological side effects including pruritus and rash. Abnormal hepatic enzyme levels and raised serum creatinine have occasionally been reported. Potentially Fatal: Severe GI bleeding; nephrotoxicity; blood dyscrasias.

Interaction

Hypersensitivity to aspirin or NSAIDs; moderate to severe renal impairment; pregnancy (3rd trimester); history of peptic ulceration or GI bleed; patients with infections.

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